This implementation study will create infrastructure to chart the experimentally sampled conformational diversity of native proteins by exploiting data from the PDB, augmented with results of state-of-the-art computational tools. By integrating resources and tools, workflows will be developed to:

• compare and cluster different conformations adopted by homologs of the same protein and
• identify protein regions with different flexibility properties. 

Pipelines will be created to characterize conformational ensembles in terms of:

Though the Plant Sciences Community has already implemented some critical elements of its roadmap, the project plan for this community implementation study features three key objectives, with each objective addressed in a corresponding work package:

The aim of this new strategic implementation study (SIS) is to build on the current progress made through the ongoing implementation study, enabling the adoption and deployment of protocols and services by the broader ELIXIR community at scale.

The first SIS Containers study (2019-2021) has successfully convened and established a growing ELIXIR wide consensus on high-level community-driven service needs and related standards including:

With intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) now recognised as major determinants in cellular regulation, the ELIXIR IDP community white paper presents a roadmap for

Building on the knowledge and experience gained during the piloting of the RI-PATHS approach, an ELIXIR-funded Staff Exchange project, and related work done elsewhere in ELIXIR, this project aims to increase capacity in impact evaluation across a set of national ELIXIR Nodes.