DIDA (DIgenic diseases DAtabase) is a database that provides detailed information on genes and associated genetic variants involved in digenic diseases, the simplest form of oligogenic inheritance. The database was developed at the Interuniversity Institute of Bioinformatics in Brussels (IB)² and currently includes 258 digenic combinations involved in 54 different digenic diseases. These combinations are composed of 448 distinct variants, which are distributed over 169 distinct genes. The web interface provides browsing, exploration and search functionalities, as well as documentation and help pages, general database statistics and references to the original publications from which the data have been collected. The possibility to submit novel digenic data to DIDA is also provided.
DIDA is published in the Nucleic Acids Research Database issue 2016 and has been selected as a NAR 2016 Breakthrough paper. The manuscript can be accessed here and an in-depth analysis of the different types of digenic diseases, i.e. true digenic and composite, in DIDA can be found here.
DIDA is part of the IBsquare Toolbox for Oligogenic Analysis which is one of ELIXIR Belgium’s Node Services.